Maternal or Infant Antiretroviral Drugs to Reduce HIV-1 Transmission

Maternal or infant antiretroviral drugs to reduce HIV-1 transmission.

BACKGROUND We evaluated the efficacy of a maternal triple-drug antiretroviral regimen or infant nevirapine prophylaxis for 28 weeks during breast-feeding to reduce postnatal transmission of human immunodeficiency virus type 1 (HIV-1) in Malawi. METHODS We randomly assigned 2369 HIV-1-positive, breast-feeding mothers with a CD4+ lymphocyte count of at least 250 cells per cubic millimeter and t...

Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to reduce Perinatal HIV-1Transmission in the United States

Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to reduce Perinatal HIV-1Transmission in the United States

rapidly. The Task Force has a mechanism to update recommendations on a regular basis, and the most recent information is available on the HIV/AIDS Treatment Information Service website (http://www.hivatis.org). Revisions to the December 5, 2001 Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant Women Infected with HIV-1 for Maternal Health and for Reduc...

Antiretroviral drugs for preventing mother-to-child transmission of HIV in sub-Saharan Africa: balancing efficacy and infant toxicity.

OBJECTIVE Antiretroviral drugs can prevent mother-to-child transmission of HIV infection, but in-utero antiretroviral exposure may be associated with neurologic symptoms due to mitochondrial toxicity. We sought to identify the currently recommended regimen to prevent mother-to-child transmission that optimally balances risks of pediatric HIV infection and neurologic mitochondrial toxicity. DE...

Infant feeding and HIV-1 transmission.

Anna Coutsoudis and colleagues present a potentially important piece of the puzzle concerning the transmission of HIV-1 through breast-feeding in the first few months of life. Breast-feeding poses a substantial risk of acquiring HIV-1 infection for the baby of an HIV-1-infected mother. Samples from 549 infants were tested by HIV-DNA PCR on day 1 and at ages 1 month and 3 months. Results reve...